Table 1.
Plasma chemistries in adenine-fed rats receiving daily intraperitoneal injections of NaPPi in 10 ml/kg
| Baseline | PPi dose, μmol/kg/day
|
|||
|---|---|---|---|---|
| 0 (n=15) | 80 (n=6) | 160 (n=7) | ||
| Body weight (g) | 324±1 | 223±6 | 220±10 | 230±5 |
| Urea (mmol/l) | 10.2±0.5 | 23±2 | 24±3 | 36±6* |
| Calcium (mmol/l) | 1.96±0.04 | 1.79±0.10 | 1.62±0.09 | 1.99±0.13 |
| Phosphorus (mmol/l) | 1.4±0.1 | 6.9±0.8 | 6.7±0.4 | 6.7±0.6 |
| Alkaline phosphatase (IU/l) | NA | 76.3±1.2 | 54.8±1.5* | 80.0±3.9 |
Abbreviations: NA, not assayed; NaPPi, sodium PPi; PPi, pyrophosphate.
*
P<0.05.
Baseline chemistries were obtained from six rats of similar age fed normal rat chow (23% protein).
Results are means±s.e.m.