Table 2.
Parameters of bone formation in normal rats and in adenine-fed rats treated with or without 160 μmol PPi/kg/day
| Normal (6) | Uremic
|
||||
|---|---|---|---|---|---|
| No calcitriol
|
Calcitriol
|
||||
| Control (7) | PPi (7) | Control (6) | PPi (6) | ||
| Bone volume (% of total) | 12.5±1.6 | 14.2±2.5 | 15.8±1.6 | 14.4±1.1 | 11.4±0.8 |
| Osteoblasts (no. per 100 mm) | 29±2 | 494±198 | 176±82 | 453±110 | 399±278 |
| Osteoblast surface | 0.39±0.04 | 6.2±2.2 | 2.5±1.1 | 5.6±1.3 | 5.3±3.3 |
| Osteoid thickness (μm) | 3.6±0.5 | 4.6±0.9 | 4.4±1.1 | 4.6±0.9 | 3.5±0.3 |
| Mineral apposition (μm/day) | 2.0±0.3 | 5.7±0.6 | 5.5±0.6 | 6.8±0.5 | 6.8±0.6 |
| Bone formation (mm3/cm2/year) | 9.9±1.9 | 24.9±6.3 | 21.9±5.2 | 43.2±8.5 | 45.3±6.2 |
Abbreviation: PPi, pyrophosphate.
None of the differences between control and PPi-treated rats were significant by Mann–Whitney U-test.
Parentheses indicate the number of animals in each group.