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. Author manuscript; available in PMC: 2011 Sep 30.
Published in final edited form as: Nat Rev Drug Discov. 2008 Oct 17;7(11):900–907. doi: 10.1038/nrd2684
Criterion Weight
Enzymes 100
Low mass(<100 kDa) 20
No transmembrane domains 20
Crystal structure 50
Structural model (in Modbase) 30
Present in all trypanosomatids 25
Absent in humans 25
Essential in at least one model organism 40
Druggability > 0.6 35
Compound desirability > 0.3 35
Chemical and/or genetic validation 50
Publication(s) in PubMed 35
Maximum possible cumulative weight 465