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. Author manuscript; available in PMC: 2012 Oct 5.
Published in final edited form as: J Am Chem Soc. 2011 Sep 13;133(39):15316–15319. doi: 10.1021/ja2066913

Table 1.

Ligand Screen and Reaction Condition Optimization a

graphic file with name nihms323794t1.jpg
Entry 1a : 2a Pd • ligand Ligand Time Yield (%) b
1 1.05:1.00 20% L1 30 min NR
2 1.05:1.00 20% L2 30 min 59
3 1.05:1.00 20% L3 30 min <5
4 1.05:1.00 20% L4 30 min <5
5 1.05:1.00 20% L5 30 min 29
6 1.05:1.00 20% L6 30 min <5
7 1.05:1.00 20% L7 30 min 13
8 1.00:2.40 30% L2 40 min 91
a

Reactions were carried out under ambient conditions without the need of insert gas protection.

b

Yields were derived by comparing the integration area of 3a in their respective HPLC traces to that of a standard curve. See Supporting Information for details.