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. Author manuscript; available in PMC: 2012 Oct 5.
Published in final edited form as: J Am Chem Soc. 2011 Sep 13;133(39):15316–15319. doi: 10.1021/ja2066913

Table 2.

Aryl Iodides in Aqueous Copper-Free Sonogashira Cross-Coupling Reactions a

graphic file with name nihms323794t2.jpg
Entry Ar-I Pd • L2 Conversion (%)b
1 graphic file with name nihms323794t3.jpg 30% 84
2 graphic file with name nihms323794t4.jpg 30% 95
3 graphic file with name nihms323794t5.jpg 30% 77
4 graphic file with name nihms323794t6.jpg 30% 88
5 graphic file with name nihms323794t7.jpg 30% 70
6 graphic file with name nihms323794t8.jpg 30% 72
a

Reactions were carried out on a 4 µmol scale at 37 °C with 1:2a ratio of 1:2.4.

b

Conversions were calculated based on the disappearance of aryl iodides in the reaction mixtures in the HPLC. See Supporting Information for details.