FIGURE 3.

Pain relief at 2 hours as a function of time of initiating treatment after start of migraine. Pain relief rates at 2 hours were significantly higher for patients treated with MAP0004 than with placebo when assessed at ≤1 hour after onset of the migraine (†P<.001), between >1 and ≤4 hours after onset (†P<.001), between >4 and ≤8 hours after onset (^*P=.008), and >8 hours after onset (‡P=.007). P values were calculated using the Cochran-Mantel-Haenszel test controlling for baseline pain score; exploratory end points were not adjusted for multiplicity. Therapeutic gain (active minus placebo) was similar at all time points.