Table 5.
Impact of PI resistance mutations on bevirimat resistance
| Virus | Fold resistance bevirimat |
||||
|---|---|---|---|---|---|
| - | V362I | A364V | S368N | V370A | |
| HXB2 | - | 2.8 | > 150 | 6.6 | > 150 |
| PR-1 (20R-36I-54V-63P-71I-82T) | 0.6 | 2.1 | > 150 | 6.0 | > 150 |
| PR-2 (431V-10I-13V-36I-46I-54V-62V-63P-71T-82A-90M-93L) | 2.1 | > 150 | > 150 | > 150 | > 150 |
Levels of bevirimat resistance caused by single CA/p2 mutations in different protease backgrounds are given. Resistance is expressed as fold change in EC50 compared to HXB2. All numbers are averages of at least two separate experiments.