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. 2011 Sep 30;6(9):e24074. doi: 10.1371/journal.pone.0024074

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Berta et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A, C) TUNEL and PCNA labeling, respectively, in erd is sustained between 7.7–14.1 wks with many labeled cells in the ONL of the superior (Sup.) and inferior (Inf.) meridians (data from both quadrants combined for normal; data points expressed as mean ±1 SD). Color insets illustrate the labeled cells (green) from a 7.7 wk old mutant animal for the corresponding assay in sections with hCAR antibody that labels all cones (red). (B) The number of photoreceptors in the outer nuclear layer (ONL), expressed as the mean number of rows of nuclei, remains relatively constant until 14.1 wks, and then decreases. Sup.A1/Inf.A1 = superior/inferior area 1, 2000±500 µm from the optic disc; Sup.A2/Inf.A2 = superior/inferior area 2, mid point ±500 µm between optic disc and ora serrata. For the ONL, the mean nuclei counts are presented. Between 4.3–14.1 wks of age, all the SD for ONL were ≤15% of the mean, with greater than 60% of the values being less than 10% of the mean.