Table 2. CABG Genomics validation study: Nineteen validated SNPs associated with ventricular dysfunction after primary coronary artery bypass grafting with cardiopulmonary bypass.^* .

SNP	Chromosome, Location NCBI hg36	Gene	GWAS or Additional SNP	Minor Allele/Major Allele	MAF VnD Cases (n = 71)/Controls (n = 715)	Best Genetic Model in GWAS†	Unadjusted Odds Ratio	Univariate Asymptotic P value	Multivariable Adjusted Odds Ratio	Multivariate Asymptotic P value
rs1287820	Chr 1, 180,855,954		GWAS	G/C	0.32/0.20	Additive	2.00	0.0004	2.26	0.0002
rs17691914	Chr 3, 34,937,807		GWAS	G/A	0.19/0.08	Additive	2.74	2.7×10−5	2.96	6.0×10−5
rs9835451	Chr 3, 34,946,568		GWAS	G/A	0.22/0.11	Additive	2.14	0.0005	2.29	0.001
rs17358517	Chr 3, 59,660,772		GWAS	T/C	0.38/0.23	Additive	2.07	9.6×10−5	2.14	0.0002
rs17061085	Chr 3, 59,666,765		Additional	A/G	0.26/0.13	Additive	2.04	0.0001	2.08	0.0004
rs9837024	Chr 3, 78,534,327		GWAS	G/A	0.36/0.22	Additive	2.09	0.0002	1.95	0.002
rs4242051	Chr 5, 54,234,532		GWAS	T/C	0.40/0.28	Recessive	3.30	0.0002	2.73	0.005
rs6459959	Chr 7, 155,390,912		GWAS	C/G	0.51/0.36	Additive	1.88	0.0004	1.78	0.002
rs6459961	Chr 7, 155,391,016		GWAS	C/A	0.51/0.36	Additive	1.88	0.0004	1.78	0.002
rs10104640	Chr 8, 40,762,563	ZMAT4	GWAS	A/C	0.38/0.27	Recessive	3.43	6.7×10−5	3.51	0.0003
rs10500830	Chr 11, 16,441,827	SOX6	GWAS	A/G	0.28/0.19	Recessive	5.37′	3.6×10−5	6.18	0.0001
rs12279572	Chr 11, 117,458,170	TMPRSS4	GWAS	G/A	0.36/0.29	Recessive	3.61	3.5×10−5	3.61	0.0002
rs7975290	Chr 12, 26,505,185	ITPR2	GWAS	G/A	0.14/0.05	Additive	2.91	8.4×10−5	3.53	4.5×10−5
rs10773689	Chr 12, 128,686,079	TMEM132D	GWAS	A/C	0.24/0.39	Additive	0.50	0.0007	0.47	0.0005
rs10519861	Chr 15, 31,773,350	RYR3	GWAS	T/G	0.56/0.40	Additive	2.00	0.0001	2.18	0.0001
rs8027394	Chr 15, 76,404,968		GWAS	T/C	0.48/0.30	Additive	2.06	4.2×10−5	2.12	0.0002
rs12593362	Chr 15, 76,421,786		Additional	T/G	0.47/0.31	Additive	1.99	0.0001	2.10	0.0002
rs8058644	Chr 16, 48,454,181		GWAS	T/C	0.18/0.07	Additive	2.61	6.8×10−5	2.86	8.7×10−5
rs16974035	Chr 18, 10,269,356		GWAS	G/A	0.49/0.34	Additive	1.86	0.0005	1.96	0.0005

Chr = chromosome; GWAS = genome-wide association study; MAF = minor allele frequency; SNP = single nucleotide polymorphism; VnD = ventricular dysfunction.

*19 SNPs with univariate asymptotic and point-wise permuted P values≤0.0005 (allelic, additive, or recessive models) were selected from the CABG Genomics validation study's 63 assessed SNPs (Table S2) for further assessment.

†When GWAS data indicated allelic genetic model as the most significant, Table 2 reports additive model results for the validation study to show multivariate adjusted results.