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. 2011 Sep 30;6(9):e25168. doi: 10.1371/journal.pone.0025168

Figure 6. TGF-β-induced DNMT1 predicts prostate cancer recurrence.

Figure 6

A. Kaplan Meier curve was generated for significant variables. TGF-β1, p-Smad2, p-ERK, pathologic Gleason Score and DNMT1, TβRI were all predictors of biochemical recurrence. B. DNMT1, pathologic Gleason score was analyzed as two different groups, and there was a significant difference in the survival curves. C. Cox Proportional Hazards Model only includes DNMT1, grouped as below 3 and 3, and pathologic Gleason score sum of patients, grouped as below 8, or above. Using our dataset, patients with tissue level DNMT1 of 3 had a 3.53 times higher biochemical recurrence rate than patients with lower tissue levels of DNMT1. Patients with Gleason score sum ≥8 have a 2.27 times higher biochemical recurrence rate compared to patients with Gleason score sum <8.