. 2011 Sep 30;6(9):e25559. doi: 10.1371/journal.pone.0025559

Table 2. Cumulative analysis of significant SNPs in TGF-β pathway on ovarian cancer risk.

No. of unfavorable genotypes	Case/control (number of case/number of control)	OR (95% CI)^*	P	Bootstrapped95% CI
2–4	31/9	1 (Ref.)
5–7	174/122	2.45 (1.12–5.33)	0.02424	1.13–6.20
8–10	177/220	4.42 (2.04–9.57)	0.00017	2.07–11.18
11–13	32/61	6.75 (2.83–16.12)	1.68×10⁻⁵	2.78–18.47
P for trend			1.67×10⁻⁸

Note: Unfavorable genotypes: BMP2: rs235757 GG; INHBC: rs2228225 AG+GG and rs4760259 (CT+TT); SMAD1: rs11724777 TT; SMAD2: rs1792689 CT+TT; SMAD3: rs10152307 CT+TT and rs7183244 CT+TT; SMAD6: rs4147407 CT+TT, rs4075546 AG+GG, rs16953584 GG, and rs4776318 AC+CC; SMAD7: rs17186485 AG+GG; TGFB1: rs8179181 CT+TT.

*Adjusted by age and ethnicity.