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. 2011 Sep 30;6(9):e25653. doi: 10.1371/journal.pone.0025653

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Ljungdahl et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Composite MALDI IMS ion images from one single section of a high-dyskinetic animal reveal regional a distinct regional discrepancy between locally low Dyn B (green) and corresponding high Leu-Enk-Arg (red) levels in the dorsolateral SN (arrow). (B, C) Dynorphin metabolites Leu-Enk-Arg-Arg and aNeo(1–7) were also upregulated in the lateral, but not medial part of SN in HD animals (arrowhead). (D) Nigral levels of DynA (1–8), DynA (1–17), and Substance P (E) were not associated with any treatment-induced changes. Scale bar = 2 mm.