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. 2011 Sep 30;6(9):e25787. doi: 10.1371/journal.pone.0025787

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Wulfken et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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MicroRNAs were profiled in serum and tissue of patients with clear cell renal cell carcinoma (ccRCC) and healthy controls (each n = 6) using the TaqMan Low Density Array; 36 microRNAs were upregulated in RCC tissue and serum of RCC patients (Phase-1). Seven microRNAs were chosen for verification using real-time PCR in a cohort of 33 ccRCC and 30 healthy individuals (Phase-2). In Phase-3, the finding of increased serum miR-1233 levels in RCC patients was confirmed in a multicentre cohort of 84 RCC, 93 healthy and 13 benign renal tumors (BRT). MicroRNA recovery (as determined using quantification of the synthetic miR-39) was similar in the study centers (UKB, UKM, UKS); the level of miR-1233 were somewhat higher in patients from UKM.