Figure 1.
The processing steps for the age-specific template creation. (A). In Step 0, the rigid registration occurred using FLIRT to a average template with 6 DOF rotation, with the resulting MRI volume the same size as the original to keep pediatric sizes. The rigidly registered brains (V0) were averaged to create a rough template (A0). This template was used as the first tentative template in Step 1. (B) With each iteration of step N, the rigidly registered brains were nonlinearly registered to an iterative average (An-1), and transformed and then averaged to create a new average (An) for the next iteration.