. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Eur J Cancer Prev. 2011 Nov;20(6):539–548. doi: 10.1097/CEJ.0b013e328348fc21

Table 1. Associations of obesity or body mass index (BMI) with blood levels of insulin and insulin-like growth factor system components in adults and children.

Obesity (men)	↑ insulin	↓ IGFBP-1	Ref. 128
Obesity (men)	↑ free IGF-I	↓ IGFBP-2

Overweight/obesity (women)	↑ insulin	↓ IGFBP-1	Ref. 129
Overweight/obesity (women)	↑ insulin	↓ IGFBP-2

BMI (men)	↑ IGFBP-3	↓ IGFBP-2	Ref. 130

BMI (men and women)	↑ IGF-II	↓ IGFBP-2	Ref. 131

BMI (women)	↑ IGF-II		Ref. 132
	↑ IGFBP-3

	↑ bioactive/total	↓ total IGF-I	Ref. 133
	IGF-I	↓ IGFBP-1

Obesity (children)	↑ insulin	↓ IGFBP-1	Ref. 134
	↑ IGF-II	↓ IGFBP-2
	↑ IGFBP-3
	↑ IGFs/IGFBPs

	↑ insulin	↓ IGFBP-2	Ref. 135

	↑ insulin		Ref. 136
	↑ IGF-I
	↑ IGFBP-3

	↑ insulin		Ref. 137
	↑ IGFBP-3

Only those factors that exhibited a statistically significant association with obesity or BMI within a given study are listed. IGF-I, insulin-like growth factor-I; IGFBP-1, insulin-like growth factor-binding protein-1; IGFBP-2, insulin-like growth factor-binding protein-2; IGFBP-3, insulin-like growth factor-binding protein-3; IGF-II, insulin-like growth factor-II.