Table 3.
Odds ratios (and 95% confidence intervals) for breast cancer by category of maternal weight gain in pregnancy, according to age at diagnosis and ER status of the tumor
Maternal weight gain in pregnancy | Age at diagnosis
|
ER status of tumor
|
||||||
---|---|---|---|---|---|---|---|---|
Cases <50 years | Cases ≥ 50 years | ER+ Cases | ER- Cases | |||||
Wt gain <10 lbs | 19/69 | 0.95 (0.59–1.54) | 9/69 | 0.93 (0.46–1.89) | 15/69 | 0.95(0.55–1.63) | 8/69 | 1.23 (0.57–2.63) |
Wt gain 10–14 lbs | 54/222 | 0.93 (0.69–1.27) | 45/222 | 1.22 (0.83–1.80) | 56/222 | 1.13 (0.82–1.56) | 20/222 | 1.06 (0.62–1.79) |
Wt gain 15–19 lbs | 113/322 | 1.05 (0.83–1.34) | 47/324 | 1.09 (0.75–1.61) | 83/322 | 1.08 (0.81–1.43) | 30/324 | 0.95 (0.60–1.51) |
Wt gain 20–29 lbs | 173/514 | 1.00 (ref) | 64/514 | 1.00 (ref) | 120/514 | 1.00 (ref) | 50/514 | 1.00 (ref) |
Wt gain 30–40 lbs | 78/207 | 1.11 (0.85–1.45) | 34/207 | 1.22 (0.80–1.86) | 54/207 | 1.11(0.80–1.53) | 29/207 | 1.54 (0.97–2.45) |
Wt gain 40+ lbs | 21/79 | 0.90 (0.57–1.42) | 6/79 | 0.65 (0.28–1.49) | 19/79 | 1.09 (0.66–1.78) | 4/79 | 0.59 (0.21–1.65) |
p-trend* | 0.69 | 0.56 | 0.99 | 0.56 |
Odds ratios are adjusted for birth year of nurse, cohort, family history of breast cancer in nurses' mother or sister (yes/no; as reported by nurse), maternal smoking during pregnancy (no, yes <25 cigs/day, yes >=25 cigs/day).
p-trend from model using the midpoint of each weight gain category as a continuous variable.