Table 2.
The significantly different regions when comparing between the AD and MCI groups (AD > MCI) using the MD with (gmMD) and without (nMD and pMD) minimizing the effects of the background gradients (corrected FDR (p < 0.01) as the cluster level; one-way ANOVA tests)
| Talairach coordinate | Cluster | T | Z | Region | BA ROI# | |||
|---|---|---|---|---|---|---|---|---|
| X | Y | Z | ||||||
| gm | 50 | −4 | −22 | 602 | 5.56 | 5.27 | R. temporal subgyrus, WM | |
| 50 | −18 | −4 | 602 | 4.83 | 4.64 | R. superior temporal gyrus, GM | 22 | |
| 58 | −6 | −4 | 602 | 4.8 | 4.61 | R. superior temporal gyrus, WM | ROI1 | |
| −32 | −24 | −22 | 264 | 5.32 | 5.07 | L. limbic parahippocampal gyrus, WM | ROI2 | |
| 38 | −72 | 32 | 323 | 4.94 | 4.73 | R. occipital subgyrus, WM | ||
| −4 | 62 | 14 | 303 | 4.81 | 4.62 | L. superior frontal gyrus, GM | 9 | |
| −4 | 50 | 20 | 303 | 4.65 | 4.47 | L. medial frontal gyrus, WM | ||
| −6 | 62 | −4 | 303 | 4.41 | 4.26 | L. medial frontal gyrus, WM | ||
| Neg | 50 | −6 | −20 | 1,041 | 5.78 | 5.46 | R. temporal subgyrus, WM | |
| 50 | −18 | −4 | 1,041 | 5.02 | 4.8 | R. superior temporal gyrus, GM | 22 | |
| 58 | −6 | −4 | 1,041 | 5.03 | 4.81 | R. superior temporal gyrus, WM | ROI1 | |
| −30 | −22 | −22 | 546 | 5.73 | 5.41 | L. limbic parahippocampal gyrus, WM | ||
| 38 | −72 | 30 | 432 | 5.18 | 4.95 | R. temporal subgyrus, WM | ||
| 36 | −72 | 6 | 432 | 3.94 | 3.83 | R. middle occipital gyrus, WM | ||
| −26 | −6 | −32 | 546 | 4.35 | 4.21 | L. limbic parahippocampal gyrus, WM | ||
| −32 | 2 | −22 | 546 | 4.49 | 4.33 | L. limbic parahippocampal gyrus, WM | ||
| Pos | 40 | −74 | 30 | 1,759 | 4.82 | 4.63 | R. middle temporal gyrus, WM | ROI3 |
| −4 | 62 | 10 | 1,024 | 5.38 | 5.11 | L. medial frontal gyrus, GM | ||
| −4 | 50 | 20 | 1,024 | 5.44 | 5.17 | L. medial frontal gyrus, WM | 10 | |
| −6 | 62 | −4 | 1,024 | 5.23 | 4.98 | L. medial frontal gyrus, WM | ||
| 24 | −86 | 16 | 1,759 | 5.74 | 5.42 | R. occipital ceneus, WM | ROI4 | |
| 54 | −64 | 6 | 1,759 | 5 | 4.78 | R. middle temporal gyrus, WM | ||
| −56 | −44 | 32 | 523 | 5.22 | 4.98 | L. parietal supramarginal gyrus, WM | ||
| −50 | −38 | 30 | 523 | 4.41 | 4.26 | L. interior parietal lobule, WM | ||
| −58 | −34 | 18 | 523 | 4.4 | 4.25 | L. superior temporal gyrus, WM | ||
| −30 | 2 | −22 | 732 | 4.49 | 4.33 | L. limbic parahippocampal gyrus, GM | 34 | |
| −24 | −4 | −32 | 732 | 3.65 | 3.56 | L. limbic uncus, WM | ROI5 | |
| 50 | −4 | −22 | 779 | 5.34 | 5.09 | R. temporal subgyrus, WM | ||
| −32 | −26 | −22 | 732 | 5.01 | 4.79 | L. limbic parahippocampal gyrus, WM | ROI2 | |
| 40 | 40 | 26 | 408 | 4.71 | 4.52 | R. middle frontal gyrus, GM | 9 | |
| 50 | −6 | −4 | 779 | 4.6 | 4.43 | R. sublobar insula | ||
| 48 | 30 | 28 | 408 | 4.52 | 4.36 | R. middle frontal gyrus, GM | 9 | |
| 50 | −18 | −4 | 779 | 4.66 | 4.49 | R. superior temporal gyrus, GM | 22 | |
| 46 | 46 | 8 | 408 | 4.03 | 3.91 | R. middle frontal gyrus, WM | ||
gm geometric mean, Neg negative, Pos positive, BA Brodmann area, R. right, L. left, WM white matter, GM gray matter