. Author manuscript; available in PMC: 2011 Oct 1.

Published in final edited form as: Angew Chem Int Ed Engl. 2011 Feb 8;50(11):2621–2624. doi: 10.1002/anie.201007689

Table 2.

Inhibition constants for fibrin fragment DD(E) binding, K_i (µM), and per gadolinium relaxivities (r₁ (mM⁻¹s⁻¹) determined at 1.5T, 37 °C in Tris buffered saline (TBS), human plasma, or bound to human fibrin for the contrast agents.^a % inc refers to the percentage increase in r₁ going from plasma to fibrin.

Compound	K_i	r₁ TBS	r₁ plasma	r₁ fibrin	% inc
Gd2-Pep-Gd2	4.7	13.0	13.1	18.0	37%
Gd2-Gly2-Pep-Gd2	4.0	12.4	13.0	17.8	37%
Gd2-T-Pep-Gd2	3.5	13.3	13.1	28.0	114%

^[a]

Uncertainties estimated at ±10%.