Figure 12.

Cross-model validation of virulence expression in Pseudomonas agents in experiments of endogenous opioid production manifesting as suppression of commensal bacterial populations. This figure demonstrates the results of simulations of the production of endogenous dynorphin by GEC agents in response to a simulation of 20 minutes of ischemia, activation of the virulence factor HQNO in the Pseudomonas agents and its effect on the suppression of the growth of commensal bacteria (compare to Additional File 6).