Figure 17.

GMABM response to host stress without phosphate depletion. Selected frames from the model interface taken at 6, 12, 24 and 48 hrs of simulated time during simulation of systemic inflammation (IFN-ϒ) without phosphate depletion in the integrated GMABM. Pseudomonas agents are red pentagons and intact tight junctions are seen as the purple background. This set of simulations demonstrate only mild barrier disruption (grey-black areas), consistent with experimental findings that immune activation alone in in vivo models is not sufficient to generate a clinically significant injury.