Table 8.
LoCo variation: decoy discrimination
| RB1 | RB10 | RMSDdecoy | Zdecoy | CCdecoy | FEdecoy (%) | log(PB1) | log(PB10) | |
|---|---|---|---|---|---|---|---|---|
| LoCo BEST | 25.5 | 5.6 | 3.01 | 1.005 | 0.517 | 33.0 | -0.982 | -1.654 |
| LoCo WORST | 175.0 | 53.0 | 4.09 | 0.748 | 0.374 | 24.0 | -0.665 | -1.432 |
| LoCo AVERAGE | 112.5 | 26.5 | 3.68 | 0.909 | 0.481 | 29.9 | -0.778 | -1.562 |
| LoCo CHOSEN | 154.8 | 5.6 | 3.51 | 0.938 | 0.505 | 31.4 | -0.864 | -1.640 |
| DFMAC | 108.9 | 13.8 | 3.64 | 1.024 | 0.533 | 31.6 | -0.825 | -1.586 |
| RF_CB_SRS_OD | 172.8 | 52.5 | 4.11 | 0.914 | 0.457 | 28.4 | -0.761 | -1.524 |
| ProSa 2003 | 118.2 | 24.8 | 3.82 | 0.931 | 0.493 | 32.3 | -0.755 | -1.650 |
| Server BEST | 90.7 | 25.3 | 3.81 | 0.725 | 0.416 | 27.3 | -0.671 | -1.434 |
| Server WORST | 231.3 | 71.3 | 5.83 | -0.001 | 0.165 | 7.6 | -0.359 | -1.043 |
| Server AVERAGE | 159.3 | 41.5 | 4.64 | 0.494 | 0.328 | 20.2 | -0.544 | -1.306 |
Best, worst and average performance for LoCo across all 84 parameter sets tested is compared with the chosen LoCo parameter set, the three best-performing of the other potentials, and the best, worst and average performance of all 26 remaining potentials from the Jernigan Lab server. All best, worst, and average values are for each individual performance measure; no single set contained all those values. All reported measures are averages over the 77 decoy sets in the final testing group. Lower scores are better for RB1, RB10, RMSDdecoy, log(PB1) and log(PB10). Higher scores are better for Zdecoy, CCdecoy and FEdecoy. The average performance for LoCo among all 84 parameter sets exceeds all other functions except DFMAC in RMSDdecoy and log(PB1). The LoCo average betters all other functions except DFMAC and ProSa 2003 in log(PB10). All metrics are defined in Performance measures at the end of Methods.