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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Prog Lipid Res. 2011 Jul 23;50(4):403–410. doi: 10.1016/j.plipres.2011.07.002

Figure 6. Hmg1 activity is regulated post-translationally by phosphorylation under the control of the Insig homolog, Ins1, in S. pombe.

Figure 6

Phosphorylation of Hmg1 decreases enzyme activity. Extracellular glucose suppresses activity of the phosphatase Ppe1 through Sds23 thereby preventing Hmg1 dephosphorylation. Osmotic stress stimulates Hmg1 phosphorylation through the MAP kinase Sty1. Ins1 is strictly required for Hmg1 phosphorylation. The enzymes that directly phosphorylate and dephosphorylate Hmg1 have not been identified.