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Insig function in mammals, S. cerevisiae and S. pombe
| Insig homolog | Binds HMGR | Regulated binding | Insig function | |
|---|---|---|---|---|
| Mammalian HMGR | Insig-1 | Yes | Yes | HMGR degradation |
| Sc Hmg1p | Nsg1p | Yes | ? | ? |
| Sc Hmg2p | Nsg1p | Yes | ? | Hmg2p stabilization |
| Sp Hmg1 | Ins1 | Yes | ? | Hmg1 phosphorylation |
