Table 1.
Recipient and donor demographics.
| Group 1 Unsensitized N=178 |
Group 2A 3rd Party Sensitized pkPRA=0 N=214 |
Group 2B 3rd Party Sensitized pkPRA>0 N=149 |
Group 3 Donor Sensitized N=46 |
p value | |
|---|---|---|---|---|---|
| LD (%) | 78 | 67 | 60 | 70 | 0.003 |
| Female (%) | 21 | 51 | 50 | 61 | <0.0001 |
| Mean age | 42.8 +/− 18.1 | 43.2 +/− 21.6 | 47.4 +/− 17.3 | 42.5 +/− 17.0 | 0.08 |
| Recipient race (%C) | 83 | 88 | 84 | 76 | 0.56 |
| Diabetic (%) | 29.2 | 37.8 | 30.9 | 13.0 | 0.008 |
| Retransplant (%) | 0 | 12 | 22 | 44 | <0.0001 |
| Mean # Tx | 1.0 +/− 0 | 1.1 +/− 0.4 | 1.3 +/− 0.6 | 1.6 +/− 0.8 | <0.0001 |
| Mean # pregnancies | 0 | 2.0 +/− 1.98 | 3.2 +/− 3.49 | 3.2 +/− 2.67 | <0.0001 |
| Mean %PRA (peak) | 0 | 0 | 32.8 +/− 33.4 | 50.6 +/− 36.3 | <0.0001 |
| Mean %PRA (current) | 0 | 0 | 23.3 +/− 31.8 | 40.4 +/− 36.0 | <0.0001 |
| Donor gender (%female) | 57 | 51 | 50 | 54 | 0.55 |
| Donor Race (%C) | 89 | 94 | 93 | 89 | 0.63 |
| Mean donor age | 39.9 +/−12.5 | 39.9 +/− 12.8 | 40.1 +/− 13.8 | 42.7 +/− 12.5 | 0.46 |
| Mean HLA mismatch | 3.6 +/− 1.7 | 3.3 +/− 1.8 | 3.0 +/− 2.1 | 4.0 +/− 1.6 | 0.002 |
| 0 HLA mismatch (%) | 6.8 | 13.6 | 23.6 | 4.4 | <0.0001 |
| Cause of graft failure | 0.25 | ||||
| Cause of recip death | 0.85 | ||||
| Dialysis at Tx (%) | 50.6 | 70.4 | 64.9 | 71.7 | 0.0002 |
| Months since 1st ever dialysis | 19.9 | 46.9 | 74.3 | 113.2 | <0.0001 |
| Median followup (m, SD) | 51.0 +/−16.4 | 52.1 +/−17.1 | 43.8 +/−18.4 | 56.0 +/−17.7 | 0.004 |
pk=peak, PRA=panel reactive antibody, LD=living donor, C=Caucasian, Tx=transplant, current=day of transplant, m=months, SD=standard deviation.