Table 2. SPM risk associated with p53 and p73 polymorphisms after index SCCHN.
Genotypes and no. of variant alleles | Total (No. = 1269) |
SPM/Total | SPM-free (No. = 1160) |
SPM (No. = 109) |
Pa | HR(95% CI)b | |||
---|---|---|---|---|---|---|---|---|---|
No. | % | % | No. | % | No. | % | |||
p53 | 0.008 | ||||||||
WW | 655 | 51.6 | 6.6 | 612 | 52.8 | 43 | 39.4 | 1.00 (Reference) | |
WP+PP | 614 | 48.4 | 10.7 | 548 | 47.2 | 66 | 60.6 | 1.58 (1.07-2.34) | |
p73 | 0.019 | ||||||||
GA+ AA | 530 | 41.8 | 6.4 | 496 | 42.8 | 34 | 31.2 | 1.00 (Reference) | |
GG | 739 | 58.2 | 10.1 | 664 | 57.2 | 75 | 68.8 | 1.68 (1.12-2.52) | |
Combined risk genotypes | 0.002 | ||||||||
Low risk group | 279 | 22.0 | 4.7 | 266 | 22.9 | 13 | 11.9 | 1.00 (Reference) | |
Medium risk group | 627 | 49.4 | 8.1 | 576 | 49.7 | 51 | 46.8 | 1.66 (1.00-3.06) | |
High risk group | 363 | 28.6 | 12.4 | 318 | 27.4 | 45 | 41.3 | 2.69 (1.44-5.00) | |
Trend test | 0.0007 |
χ2 test for differences in the distribution of p73 genotypes between the patients who developed SPM and the patients who did not.
Adjusted for age, sex, ethnicity, tobacco smoking and alcohol drinking in a Cox model.