Table 2. SPM risk associated with p53 and p73 polymorphisms after index SCCHN.
| Genotypes and no. of variant alleles | Total (No. = 1269) |
SPM/Total | SPM-free (No. = 1160) |
SPM (No. = 109) |
Pa | HR(95% CI)b | |||
|---|---|---|---|---|---|---|---|---|---|
| No. | % | % | No. | % | No. | % | |||
| p53 | 0.008 | ||||||||
| WW | 655 | 51.6 | 6.6 | 612 | 52.8 | 43 | 39.4 | 1.00 (Reference) | |
| WP+PP | 614 | 48.4 | 10.7 | 548 | 47.2 | 66 | 60.6 | 1.58 (1.07-2.34) | |
| p73 | 0.019 | ||||||||
| GA+ AA | 530 | 41.8 | 6.4 | 496 | 42.8 | 34 | 31.2 | 1.00 (Reference) | |
| GG | 739 | 58.2 | 10.1 | 664 | 57.2 | 75 | 68.8 | 1.68 (1.12-2.52) | |
| Combined risk genotypes | 0.002 | ||||||||
| Low risk group | 279 | 22.0 | 4.7 | 266 | 22.9 | 13 | 11.9 | 1.00 (Reference) | |
| Medium risk group | 627 | 49.4 | 8.1 | 576 | 49.7 | 51 | 46.8 | 1.66 (1.00-3.06) | |
| High risk group | 363 | 28.6 | 12.4 | 318 | 27.4 | 45 | 41.3 | 2.69 (1.44-5.00) | |
| Trend test | 0.0007 | ||||||||
a
χ2 test for differences in the distribution of p73 genotypes between the patients who developed SPM and the patients who did not.
b
Adjusted for age, sex, ethnicity, tobacco smoking and alcohol drinking in a Cox model.