. Author manuscript; available in PMC: 2013 Mar 1.

Published in final edited form as: Ophthalmology. 2011 Jun 25;119(3):437–442. doi: 10.1016/j.ophtha.2011.03.018

Table 3.

Comparison of prediction models for the development of primary open-angle glaucoma when the model uses unadjusted intraocular pressure (IOP) vs. IOP adjusted by formula for central corneal thickness.

	Baseline IOP (mm Hg) HR & 95% CI	CCT (40 μm decrease) HR & 95% CI	C statistic	Calibration Chi Square

OHTS prediction model^†:
Baseline age, unadjusted IOP, CCT, PSD & VCDR
Model with CCT (as above)	1.11 (1.05,1.17)	1.84 (1.53,2.21)	0.774	7.86
Model without CCT	1.12 (1.06,1.19)	n/a	0.747	3.57

Ehlers¹¹ adjusted IOP
Model with CCT	1.11 (1.05,1.17)	1.38 (1.07,1.77)	0.774	7.86
Model without CCT	1.16 (1.12,1.21)	n/a	0.770	4.60

Whitacre¹² adjusted IOP
Model with CCT	1.11 (1.05,1.17)	1.69 (1.40,2.05)	0.774	7.86
Model without CCT	1.16 (1.10,1.22)	n/a	0.754	2.59

Orssengo/Pye¹³ adjusted IOP
Model with CCT	1.10 (1.04,1.15)	1.42 (1.12,1.80)	0.775	5.32
Model without CCT	1.15 (1.11,1.19)	n/a	0.770	3.83

Doughty¹⁴ adjusted IOP
Model with CCT	1.11 (1.05,1.17)	1.50 (1.20,1.87)	0.774	7.86
Model without CCT	1.17 (1.12,1.23)	n/a	0.766	2.14

Kohlhaas¹⁵ adjusted IOP
Model with CCT	1.11 (1.05,1.17)	1.55 (1.25,1.91)	0.774	7.86
Model without CCT	1.17 (1.12,1.23)	n/a	0.763	2.43

POAG = primary open-angle glaucoma; CCT = central corneal thickness; IOP = intraocular pressure; PSD = pattern standard deviation; VCDR = vertical cup-to-disc ratio; OHTS = ocular hypertension treatment study; HR = hazard ratio; CI = confidence interval; n/a = not applicable.

All models are run with and without CCT in the model.

^†

Hazard ratios and 95% confidence intervals may differ slightly from previous reports because of slight differences in dataset freeze date. This report includes data from February, 1994 through June 1, 2002.