Table 1.
Demographic and clinical characteristics of patients and donors by group
| Training Set | Validation Set | Prospective Validation Set |
|||
|---|---|---|---|---|---|
| NA | IF/TA | NA | IF/TA | ||
| N | 5 | 13 | 8 | 19 | 36 |
| Donor Type (DDK) | 5 | 13 | 8 | 19 | 36 |
|
Time to collection
(months) |
12.4 ± 3.9 | 82.5 ± 78.0 | 12.8 ± 3.3 | 92.6 ± 66.4 | 3 months, 3.9 ± 1.3 |
| 9 months, 9.5 ± 1.1 |
|||||
| 12 months, 12.1 ± 1.2 |
|||||
| Recipient Age (yrs) | 43.6 ± 12.6 | 39.8 ± 11.3 | 44.8 ± 16.3 | 41.4 ± 11.9 | 50.5 ± 12.2 |
| Recipient Gender (M/F) | 1 / 4 | 7 / 6 | 2 / 6 | 11 / 8 | 17 / 19 |
|
Recipient Race
(C/AA/O) |
0 / 4 / 1 | 1 / 12 / 0 | 5 / 2 / 1 | 2 / 17 / 0 | 5 / 29 / 2 |
| Recipient HCV (pos) | 0 | 1 | 0 | 1 | 3 |
| Recipient CMV (pos) | 3 | 8 | 6 | 11 | 28 |
| CMV Disease (pos) | 0 | 0 | 0 | 0 | 0 |
| Donor Age (yrs) | 42.6 ± 7.3 | 33.2 ± 15 | 37 ± 13 | 37.8 ± 13.8 | 42.4 ± 15.6 |
| Donor Gender (M/F) | 2 / 3 | 7 / 6 | 2 / 6 | 8 / 11 | 19 / 17 |
| Donor Race (C/AA/O) | 0 / 5 / 0 | 7 / 5 / 1 | 5 / 2 / 1 | 12 / 5 / 2 | 21 / 14 / 1 |
| Donor HCV (pos) | 0 | 2 | 0 | 2 | 2 |
| Donor HBV cAb (pos) | 1 | 1 | 1 | 2 | 4 |
| Donor HBV sAb (pos) | 1 | 1 | 1 | 1 | 1 |
| Donor CMV (pos) | 2 | 9 | 3 | 9 | 19 |
| Donor HIV (pos) | 0 | 0 | 0 | 0 | 0 |
| CIT (min) | 1039.2 ± 434.4 |
1097.5 ± 486.2 |
1092.1 ± 240.6 |
976.1 ± 556.9 |
1186.3 ± 416.3 |
| WIT (min) | 28.6 ± 6.7 | 29.5 ± 4.3 | 29.1 ± 6.4 | 32.8 ± 10.5 | 29.1 ± 6.3 |
| PPP (min) | 362.4 ± 418.2 |
793.4 ± 785.1 |
473.5 ± 363.5 |
179.6 ± 462.2 |
550.6 ± 494.7 |
| DGF incidence | 2 | 4 | 2 | 4 | 12 |
|
Acute Rejection
incidence |
1 | 4 | 1 | 6 | 3 |
| HLA MM total | 4 ± 1.4 | 3.25 ± 2.5 | 4.3 ± 1.2 | 3.5 ± 1.6 | 4.3 ± 1.3 |
| PRA at Tx (T-cell) | 67.6 ± 38.6 | 73.5 ± 0.7 | 55.5 ± 38.0 | 50.5 ± 31.8 | 48.0 ± 35.2 |
|
eGFR 1mo
(mL/min/1.73m2) |
>60 | N/A | >60 | N/A | 53.7 ± 22.0 |
|
eGFR 3mo
(mL/min/1.73m2) |
>60 | N/A | >60 | N/A | 56.7 ± 21.1 |
|
eGFR 6mo
(mL/min/1.73m2) |
>60 | N/A | >60 | N/A | 56.0 ± 21.8 |
|
eGFR 9mo
(mL/min/1.73m2) |
>60 | N/A | >60 | N/A | 56.3 ± 25.8 |
|
eGFR 12mo
(mL/min/1.73m2) |
>60 | N/A | >60 | N/A | 54.8 ± 23.2 |
Deceased Donor Kidney (DDK), Caucasian (C), African-American (AA), Other (O), Cold Ischemia Time (CIT), Warm Ischemia Time (WIT), Pump Perfusion Preservation (PPP), Delayed Graft Function (DGF), eGFR* (estimated Glomerular Filtration Rate).
*(GFR (ml/min/1.73 m2) = 175 × (Scr)1.154 × (age in yrs)−0.203 × (0.742 if female) × (1.21 if African-American) where Scr is serum creatinine concentration (mg/dl)).