Table 3.

Cerebral sites of hemodynamic response during hand movement, speech production and combined tasks in PD patients

Cerebral areas			Hand movement			Speech production			Combined [hand + speech] task
Localisation	L/R	BA	x, y, z	Z-score	k	x, y, z	Z-score	k	x, y, z	Z-score	k
Frontal lobe
Primary motor cortex (M1)	Left	4	−29, −27, 46	Inf	1517*				−29, −27, 44	7.35	402*
Lateral premotor cortex	Left	6				−40, −17, 29	7.43	263**	−20, −15, 48	5.18	7
	Right					40, −13, 29	6.28	78**
Medial premotor cortex (SMA)	Medial	6	−4, −9, 49	5.20	5
Parietal lobe
Secondary somatosensory cortex	Left	5/7				−17, −73, 43	4.91	2
Temporal lobe
Wernicke’s area	Left	39/40				−27, −52, 34	5.04	6	−34, −42, 35	5.73	62
Secondary auditory cortex	Left	21				−59, −42, 1	5.51	7
	Right					45, −25, −3	5.20	3
Occipital lobe
Secondary and tertiary visual cortices	Left	18/19/20	4, −89, 22	5.76	24
	Right		−20, −96, 12	5.21	5
Cerebellum	Left		−22, −48, −27	5.19	19	−36, −67, −28	5.66	22	−34, −63, −30	5.19	9
	Right		20, −52, −28	Inf	720	34, −67, −30	4.91	1	13, −52, −22	7.14	537

Cerebral activation locations refer to maximal hemodynamic response sites. PD: Parkinson’s disease; L/R: left/right; BA: Brodmann’s area; x, y, z: mediolateral, rostrocaudal and dorsoventral Talairach coordinates; Z scores > 4.88 correspond to corrected p_FWE-corr values < 0.05; Inf: infinite; k: cluster size (number of voxels); M1: primary motor cortex; SMA: supplementary motor area.

^*these clusters also included the primary somatosensory cortex (BA 3/2/1);

^**these clusters also implicated the primary motor cortex (BA 4).