Figure 4.
Comparison of G6PD kinetic parameters and steady state value, recovery time, and amount of change in GSH/GSSG in individuals. (a) The relationship between V max and K mG6P and the evaluation criteria in real patients (Table 1). Dark gray dots represent G6PD-deficient patients, and the light gray dots represents the control. (b) The relationship between V max and K mG6P and the evaluation criterions in virtual G6PD patients created from randomly selected parameters (Table 2). Recovery time denotes the time required for the GSH/GSSG to return to its initial value after perturbation, and amount of change is calculated by (2) in the text. Note that a few patients exhibiting abnormal recovery time (>30 min, 0.4% the of original number of patients) have been eliminated from the plot. The data displayed here were obtained from a single simulation run, which was representative of 15 simulation runs.