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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Phys Biol. 2011 Aug 10;8(5):055002. doi: 10.1088/1478-3975/8/5/055002

Figure 2. miRNA-based feedback introduces an expression threshold in sequestration model.

Figure 2

The mean value of mRNA (A), miRNA (B) and protein (C) are shown as a function of αm for four different values of the peak miRNA transcriptional rate (σ). When σ is extremely small, m and p are proportional to αm because there is almost no miRNA synthesis. For larger σ, the miRNA-based feedback introduces a threshold at αm ≈ σ. All the asymptotic lines are parallel to each other. γm = γμ = 0.01, γp = 0.002, κ = 1.0, kp = 0.1 and kd = 200.0.