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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Phys Biol. 2011 Aug 10;8(5):055002. doi: 10.1088/1478-3975/8/5/055002

Figure 3. Increasing miRNA-mediated feedback strength sharpens the expression threshold.

Figure 3

Mean protein numbers as a function of upstream transcription rate. The different curves show how threshold expression depends on the strength of miRNA/mRNA association rate. Mean protein expression shows a crossover regime from low expression to linear expression with increasing transcription rate. As the strength of miRNA/mRNA association, κ, increases, the threshold becomes sharper. The solid curve is a perfect threshold-linear behavior. The parameters are set as γm = γμ = 0.01, γp = 0.002, σ = 0.5, kp = 0.1, kd = 200.0.