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Schematic representation of wild-type and truncated Tiam1 cDNA constructs used in this study. Proteins are depicted to scale. M, myristoylation signal; P, region rich in proline, glutamate, serine, and threonine; PHn and PHc, NH2-terminal and COOH-terminal pleckstrin homology domains; DHR, Discus-large homology region; DH, Dbl homology domain; WT, wild type.
