Figure 1.
The effects of genotype on percent prepulse inhibition (PPI) of the acoustic startle response at prepulse (onset)-to-pulse (onset) intervals of 30, 60, and 120 msec in healthy human volunteers (means and SEM, adjusted for sex and smoking): (A) the completely linked serotonin-2A receptor (5-HT2A) A-1438 G and T102C receptor polymorphisms (Tukey honest significant difference post hoc test vs. TT/AA allele group: *p < .05, **p < .01), (B) the catechol O-methyltransferase (COMT) Val158Met polymorphism, and (C) the neuregulin-1 (NRG-1) Arg38Gln polymorphism.