Table 2.
Demographic Data and Psychophysiological Parameters of Healthy Human Volunteers Grouped According to Catechol-O-methyltransferase (COMT) Val158Met Genotype
| COMT Val158Met Genotype (rs4680) | MetMet | ValMet | ValVal | Total | F/χ2 | df/dferr | p | η2 |
|---|---|---|---|---|---|---|---|---|
| n | 22 (23.7%) | 53 (57.0%) | 18 (19.4%) | 93 (100%) | ||||
| Age | 25.9 (1.3) | 26.4 (.9) | 25.7 (.9) | 26.2 (.6) | .13 | 2/92 | .88 | .00 |
| Years of Education | 16.3 (.7) | 17.1 (.4) | 17.5 (.8) | 17.0 (.3) | .79 | 2/92 | .46 | .02 |
| Men, % | 54.5 | 45.3 | 50.0 | 48.4 | .56 | 2 | .76 | — |
| Smoker, % | 27.3 | 28.3 | 16.7 | 25.8 | .98 | 2 | .61 | — |
| First Block, Amplitude of Pulse-Alone Trialsa (Arbitrary Units) | 775 (88.1) | 685 (56.8) | 749 (68.5) | 718 (42.1) | .42 | 2/88 | .66 | .01 |
| Mean Amplitude of Pulse-Alone Trialsa (Arbitrary Units) | 644 (76.6) | 561 (49.4) | 559 (60.6) | 580 (36.7) | .45 | 2/88 | .64 | .01 |
| Mean Percent Prepulse Inhibitiona (Mean Across Three SOA Conditions) | 35.8 (3.2) | 30.2 (2.1) | 34.3 (3.5) | 32.3 (1.7) | 1.28 | 2/88 | .28 | .03 |
| Percent Early Habituation of Pulse-Alone Trialsa (Between First and Second Block) | 14.7 (5.8) | 21.5 (3.8) | 26.0 (4.5) | 20.6 (2.8) | .89 | 2/88 | .41 | .02 |
| Percent Total Habituation of Pulse-Alone Trialsa (Between First and Last Block) | 28.7 (7.0) | 26.0 (4.5) | 35.8 (7.7) | 28.6 (3.3) | .60 | 2/88 | .55 | .01 |
| Habituation of Pulse-Alone Trials Across Four Blocksa (Linear Gradient Coefficient b) | −74.2 (17.8) | −57.1 (11.5) | −97.9 (19.7) | −69.1 (8.6) | 1.65 | 2/88 | .20 | .04 |
SOA, stimulus-onset asynchronies.
a
Analysis of covariance, means adjusted by covariates sex and smoking.