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HDA2 and HDA3 have sequence similarity in four domains including one with potential coiled coil structure. Domain I: HDA2 (residues 12–33), HDA3 (residues 31–52), identity 31%, similarity 52%; domain II: HDA2 (residues 84–177), HDA3 (residues 84–169), identity 36%, similarity 54%; domain III: HDA2 (residues 238–299), HDA3 (residues 180–246), identity 25%, similarity 46%; domain IV: HDA2 (residues 449–630), HDA3 (residues 475–650), identity 23%, similarity 47%.
