Table 2. Immunoreactive proteins.

A summary of proteins reactive with sera from human tularemia patients (Type A and B) or LVS vaccinees.

		Study
Locus tag	Protein Name	Control sera (n−13)	Vaccine NDBR lot 11 LVS (n=8)	Vaccine DVC lot 17 LVS (n=8)	Type B (n=12)	Type A (n=12)	Previously reported
FTT_0060	ATP synthase subunit B	-	-	-	5	1	[27], [40]
FTT_0062	ATP synthase subunit A	-	1	-	5	1	[38], [39], [40]
FTT_0064	F0F1 ATP synthase subunit beta	-	-	-	6	-	[38], [41]
FTT_0077	Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex	-	8	7	11	8	[29, 30] [27, 38], [39], [40]
FTT_0087	Aconitate hydratase	1	-	1	4	-	[29], [30], [38]
FTT_0137	Elongation factor Tu (EF-Tu)	1	-	-	1	4	[25], [29],[38], [39], [40]
FTT_1486c	Hypothetical lipoprotein	-	-	-	1	1
FTT_0143	50S ribosomal protein L7/L12	10	8	6	8	10	[25], [29],[39], [40]
FTT_0183c	30S ribosomal protein S1	3	7	5	7	-	[38], [39], [40]
FTT_0188	Cell division protein	-	-	-	1	4	[29], [38], [39], [40]
FTT_0191	Peptide chain release factor 2	-	-	-	-	1
FTT_0196c	Glutamine synthetase	-	4	2	-	-	[27], [40]
FTT_0307	Glutamyl-tRNA synthetase	-	-	-	1	-
FTT_0323	Elongation factor G (EF-G)	-	1	1	3	2	[38], [39], [40]
FTT_0350	DNA-directed RNA polymerase alpha subunit	-	5	3	4	-	[38], [40]
FTT_0373c	Nucleoside diphosphate kinase	-	-	-	-	1	[25, 40]
FTT_0380c	Glutamate dehydrogenase	-	-	-	-	1*
FTT_0407	Aminomethyltransferase	-	1	-	-	-	[40]
FTT_0408	Glycine cleavage system H protein	-	2	-	3	-
FTT_0472	Acetyl-CoA carboxylase, biotin carboxyl carrier protein subunit	1	6	3	8	7	[25], [27], [38], [39]
FTT_0504c	Succinyl-CoA synthetase subunit beta	-	2	-	-	-	[30]
FTT_0535c	Malate dehydrogenase	-	1*	-	-	-	[25]
FTT_0583	Outer membrane associated protein, fopA	-	8	3	1	6	[29], [27], [38], [39]
FTT0609	peptidase, M24 family protein	-	1*	-	-	-
FTT_0673c	Hypothetical protein FTT0673c	-	-	-	3	-
FTT_0715	Chitinase family 18 protein	-	-	-	1	-	[38], [39], [40]
FTT_0721c	Peroxidase/catalase	4	5	5	6	7	[25], [29], [30], [38], [39], [40], [41]
FTT_0726c	Glycerophosphoryl diester phosphodiesterase family protein	-	6	3	-	-	[29]
FTT_0817	Threonyl-tRNA synthetase	-	1	-	-	-	[39], [40]
FTT_0893	Phosphoribosylaminoimid azole synthetase	-	5	2	-	-
FTT_1103	Hypothetical lipoprotein	-	-	-	1	-	[29], [27], [38], [39], [40], [41]
FTT_1201c	Oxidoreductase, short-chain dehydrogenase family protein	-	1*	-	-	-	[25], [28]
FTT_1269c	Chaperone protein dnaK	1	5	7	5	8	[25], [29], [30], [27], [38], [39], [40], [41],
FTT_1281c	Sigma-54 modulation protein	-	-	-	1	-	[25], [40],
FTT_1314c	Type IV pili fiber building block protein	1	2	-	4	-	[27], [40]
FTT_1352	Hypothetical protein FTT1352	1	-	4	2	-
FTT_1357c	Intracellular growth locus, subunit C	-	3	3	-	-	[40], [41]
FTT_1365c	Fructose-bisphosphate aldolase	-	-	-	3	-
FTT_1368c	Glyceraldehyde-3-phosphate dehydrogenase	-	-	-	3	-	[25], [40]
FTT_1373	3-oxoacyl-[acyl carrier protein] synthase III	-	-	-	4	2	[38]
FTT1455c	Sugar transamine/perosamine synthetase	-	-	-	-	*
FTT_1483c	Dihydrolipoamide dehydrogenase	3	-	-	1	-	[29]
FTT_1484c	Pyruvate dehydrogenase, E2 component	-	4	3	3	10	[29, 30], [27], [38]
FTT_1485c	Pyruvate dehydrogenase subunit E1	-	-	-	-	2	[30]
FTT_1696	Chaperone protein, groEL	2	4	6	12	9	[29], [27], [38], [39], [41]
FTT_1778c	Hypothetical membrane protein FTT1778c	10	8	6	8	5	[27], [38], [39]

^*indicates protein identified from limited screen of the proteome separated in the pH range 6–11.