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. Author manuscript; available in PMC: 2012 Sep 22.
Published in final edited form as: J Med Chem. 2011 Aug 23;54(18):6234–6253. doi: 10.1021/jm200553w

Table 1.

Anti-Proliferation Activities of Noviosylated Olefin Dimers.

graphic file with name nihms320420t1.jpg
Entry n X Y SKBr3 MCF-7
Coumermycin A1a 5.0 ± 0.1 8.8 ± 0.1
16 1 H OMe >100b >100
17 2 H OMe 52.0 ± 7.8 >100
18 1 OMe Me 105.7 ± 13.2 168.0 ± 9.7
19 2 OMe Me 4.1 ± 0.5 2.61 ± 0.8
2021 1 H Me >100 53.1 ± 7.1
2121 2 H Me 1.5 ± 0.1 3.9 ± 0.7
a

Anti-proliferative activities reported from reference 23

b

Values represent mean ± standard deviation for at least two separate experiments performed in triplicate, all values presented in µM