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. Author manuscript; available in PMC: 2012 Sep 22.
Published in final edited form as: J Med Chem. 2011 Aug 23;54(18):6234–6253. doi: 10.1021/jm200553w

Table 7.

Anti-Proliferation Activities of Tricyclic Tether Dimers

graphic file with name nihms320420t19.jpg
Entry n amide positions SKBr3 MCF-7
101 0 2,6 < 100a < 100
102 1 4,8 60.1 ± 2.8 22.0 ± 3.4
103 1 3,8 < 100 < 100
104 1 2,8 < 100 < 100
105 2 4,10 59.9 ± 9.8 7.1 ± 1.6
a

Values represent mean ± standard deviation for at least two separate experiments performed in triplicate, all values presented in µM