Table 1. Case reports/series of extramammary Paget disease treated by imiquimod.
| Author (year) | Nr of cases | Age | Disease | Dosage | Treatment duration (weeks) | Follow-up (months) | Outcome | Adverse events |
|---|---|---|---|---|---|---|---|---|
| Zampogna (2002)15 | 2 | 54 72 |
scrotum, recurrent perineal, primer | 1x/d: 6d, every other day: 15w; every other day: 7.5w |
16 7.5 |
12 4 |
CR CR |
flu-like symptoms; nausea, vomiting |
| Berman (2003)14 | 1 | 68 | scrotum, recurrent | 1x/d | 6 | 6 | CR, HR | local erythema |
| Qian (2003)12 | 1 | 73 | penile shaft | 3x/week | 6 | 14 | CR, HR | minimal |
| Wang (2003)11 | 1 | 75 | vulva, recurrent | 1x/d: 6d, 2x/week: 1w, 3x/week: 5w | 7 | 0.5 | CR, HR | local irritation |
| Cohen (2006)3 | 1 | 75 | suprapubic, primer | 3x/week | 16 | 9 | CR, HR | local erythema |
| Vereecken (2007)10 | 1 | 66 | perianal, recurrent | 1x/day | 12 | 12 | CR, HR | - |
| Geisler (2008)9 | 1 | 80 | vulva, reccurent | - | - | 12 | CR, HR | - |
| Hatch (2008)8 | 2 | 68 60 |
vulva, reccurent vulva, reccurent |
every other day, 1x/d: 4w; 2x/day: 2w, every day:5w |
24 20 |
4 7 |
CR, HR CR, HR |
pain, erosion; pain, ulceration |
| Challenor (2009)7 | 2 | 48 66 |
surgical not in toto surgical not in toto |
3x/week 3x/week |
12 12 |
4 3 |
follow-up follow-up |
- |
| Bertozzi (2009)6 | 1 | 71 | vulva, reccurent | - | 8 | - | CR | local itching |
| Sendagorta (2010)5 | 3 | 66 58 82 |
vulva, primer vulva, primer vulva, primer |
both: 1x/d: 3w, every other day: 3w | 6 6 6 |
26 22 20 |
CR, HR CR, HR CR, HR |
- local irritation - |
| Tonguc (2010)4 | 1 | 65 | vulva, reccurent | every day: 3w; 1w break; every other day: 14w | 18 | 24 | CR | erosion |
| Summary of reported cases | Total: 17 |
mean: 11.4 median: 10 range: 6-24 |
mean: 11.2 median: 10.5 range: 0.5-26 |
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| CR: complete clinical remission; PR: partial clinical remission; HR: histological remission; d: day; w: week | ||||||||