Table 4.

Ranking of Exonic CpG for Potential Deleterious Impact of Genetic Variation

Rank	Criteria	Numbera
1	No CpG in humans	185,919
2	CpG in humans but nonsynonymous changes in other species or nonsynonymous in humans at a codon position not within the CpG	222,582
3	CpG in humans with nonsynonymous SNP, CpG is minor allele	5,630
4	Conserved CpG	359,388
5	CpG in humans with synonymous change in human or other species or with SNP, CpG is major allele	123,896
6	Conserved CpG within gene showing a nominally significant LRT(5)	102,738
7	CpG in humans with synonymous change in human or other species within gene showing a nominally significant LRT(5) or with human SNP where CpG is major allele	42,057

Note.—From 14,348 genes, there were 1,042,210 exonic CpG. Number is the total of CpG at each rank.

^aCpG within humans satisfying criteria.