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. 2011 Oct 3;6(10):e25590. doi: 10.1371/journal.pone.0025590

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Coolen et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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The DNA methylation levels in four samples with different rs10732516 genotypes were further investigated via clonal bisulphite sequencing. (A) MassCleave data for H19-ICR of the four genotypes. (B) Clonal bisulphite sequencing analysis of the samples confirmed the genotype of the rs10732516 polymorphism (the [A] allele highlighted in red). In addition, the hypermethylated state of the maternal rs10732516 [A] allele was confirmed. The maternal [A] allele in the [AA] and [GA] individuals displayed higher methylation levels at the 5′-end of the H19-ICR than the maternal [G] allele in [AG] or [GG] individuals (44% and 33% versus 16% and 20%, respectively; boxed regions).