Table 1. Transient expression of various GFP-coilin proteins in the presence of endogenous coilin.
| Coilin Protein | Expression | Localization | Proliferation Impact | |||
| CBs | Nucleolar | Nucleoplasmic | Other | |||
| WT | High | 95% | -- | 5% | -- | None |
| T122E | High | 95% | -- | 5% | -- | Decrease |
| ON | High | 32% | -- | 68% | -- | Decrease |
| S489D | High | 95% | -- | 5% | -- | Decrease |
| S271/272D | High | 95% | -- | 5% | -- | Decrease |
| OFF | High | 40% | 60% | -- | -- | None |
Expression denotes the ratio GFP-coilin or mutants thereof to endogenous coilin.
The data for the localization of WT, ON and OFF taken from [16].
Proliferation impact reflects the change in proliferation rate when compared to the rate of cells expressing WT GFP-coilin.