Figure 2.

Graphic illustration of simple and composite mapping of Tyrp1 expression in whole eyes. A: A significant eQTL is present at the location of Tyrp1 on Chr 4, making it a candidate cis-eQTL. B: Composite interval mapping reveals a suggestive eQTL on chromosome 9 at the location of Myo5a. The blue traces in these interval maps indicate LRS scores across the genome. Horizontal lines mark the transcript-specific significant (LRS 17) and suggestive (LRS 11) thresholds based on results of 1,000 permutations of original trait data.