Figure 5. Respiration and respiratory quotient (RQ) changes over lifespan.
A) Average respiration rate (ul C02/mg-hr) in wildtype (green) and ATP61 (red) animals over time. On days 5, 10 and 15 ATP61 animals have a modest but significantly higher respiration rate than wildtype animals; however, by day 20 ATP61 mutants show a significant decrease in respiration rate. N = 21−24 animals per time point per genotype. Error is S.E.M. Statistical analysis is student's t-test. B) Individual animal respiration rates at days 15 and 20. C) Respiratory quotient (RQ) of wildtype and ATP61 animals. There is a modest but significant, decrease of the RQ of ATP61 animals at day 5 compared to wildtype. N = 6−9 chambers per time point per genotype. Error is S.E.M. Statistical analysis is student's t-test.