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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: J Allergy Clin Immunol. 2011 Jun 22;128(4):753–760.e11. doi: 10.1016/j.jaci.2011.04.058

Table II.

Genetic associations for asthma in the Isle of Wight and replication populations

Primary population Replication populations
Population IOW pooled
samples		 IOW individual
samples		 Wessex CAMP + CARE GALA Mexico
Childhood
Asthma
Study
Genotyping platform Affymetrix 100K
GeneChip array		 Custom Illumina
Goldengate		 Kbiosciences
Kaspar
Competitive PCR		 Affymetrix 6.0 ABI Taqman and
Affymetrix 6.0† 		Illumina
550
Model Allelic Allelic Allelic Allelic Allelic Allelic
Software LatteThunder PLINK PLINK PDTphase PBAT PLINK
Statistical test Z2 p-valueb χ2 p-value TDT p-value PDT p-value FBAT p-valuec TDT p-
value
SNP Chr 1
positionsa 		Caucasian
European		 Caucasian
European		 Caucasian
European		 Caucasian
American		 African
American		 Hispanic Other
ethnicity		 Puerto
Rican		 Mexican Mexican
rs1258000 46866854 - 0.0362 0.1113 - - - - - - 0.4503
rs2289447 46890755 2.20×10−8 0.0180 0.1216 - - - - (0.5789) (0.6307) -
rs620431 46890776 - 0.0063 0.2476 - - - - - - -
rs1150068 46891505 0.0034 0.0099 0.2286 - - - - (0.6289) (0.7501) -
rs629412 46893260 - - - 0.03389 0.2568 0.1573 0.8084 - - -
rs654509 46899758 - - - 0.01141 1 0.3173 1 - - -
rs601060 46912167 - - - 0.1246 0.3532 0.5485 0.6831 0.4244 0.8297 -
rs1048380 46915125 0.0006 0.0084 0.0926 - - - - (0.6126) (0.9178) -
rs12048954 46918995 - - - 0.0859 0.0495 0.2858 0.6015 0.2119 0.5893 -
rs2275380 46920315 0.0124 0.0437 0.0312 0.1225 0.09558 0.2382 0.7518 0.1802 0.6596 0.5525
rs1150064 46920631 0.0053 0.0099 0.1576 - - - - (0.4746) (0.6892) -
rs6665021 46925107 - - - 1 1 1 1 (0.8522) (0.1577) -
rs4660956 46931073 - - - 0.1741 0.3458 0.5637 0.5316 0.62877 0.64696 -
rs6671124 46937193 - - - 0.5050 0.0065 0.5002 0.6911 0.3718 0.8732 -
rs1440487 46939662 0.4309 0.7883 0.2399 0.1593 0.0896 0.6831 0.6831 0.5611 0.7763 0.3173
rs1440486 46939825 2.26×10−5 0.0124 0.0926 - - - - (0.5806) (0.9011) -
rs10749863 46946915 - - - 0.1122 0.2513 0.5485 0.6831 0.5680 0.7829 -
rs2218189 46949405 - 0.0116 0.1576 - - - - (0.5127) (0.5738) 0.6152
rs6670495 46960495 - 0.0078 0.2222 - - - - (0.4414) (0.6293) -
rs11582403 46986540 - - - 0.9287 0.2568 0.3173 0.03251 0.13033 0.34826 -
rs6662321 46992646 - - - 0.4817 0.4111 0.5271 0.0009 (0.0841) (0.6181) -
a

Positions from HapMap Data Rel 28 PhaseII+III, August 10, on NCBI B36 assembly, dbSNP b126 CEU data

b

False discovery rate cut-off for α=0.05 is Z2 p-value=2.27×10−5

c

Data in parentheses were imputed