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. Author manuscript; available in PMC: 2012 Oct 3.
Published in final edited form as: Mol Pharm. 2011 Aug 15;8(5):1619–1628. doi: 10.1021/mp200092v

Figure 1.

Figure 1

MDCK cells treated with 50 µM chloroquine concentration for 4 hours prior to staining with Lysotracker Green (yellow, lysosomes), Mitotracker Red (blue, mitochondria) and Hoechst (red, nuclei). Cells exposed to high concentrations of chloroquine undergo profound changes in endolysosomal membrane organization. Continuous accumulation of chloroquine leads to the formation of multilamellar drug-membrane complexes that visibly bind to Lysotracker Green within the lumen of the expanded lysosomes 128. Scale bar: 5 µm.