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. Author manuscript; available in PMC: 2012 Nov 1.
Published in final edited form as: J Struct Biol. 2011 Aug 6;176(2):254–258. doi: 10.1016/j.jsb.2011.07.019

Figure 1. NS-398 bound in the cyclooxygenase channel of muCOX-2.

Figure 1

Stereo view of NS-398 bound within the cyclooxygenase channel of monomer A of the muCOX-2:NS398 crystal structure. Fo-Fc simulated annealing omit electron density, contoured at 4.5σ, is shown with the final refined model of NS-398 (black). Residues lining the cyclooxygenase channel, along with the spatial locations of the channel opening (O), channel apex (A), and COX-2-specific side pocket (SP) are labeled accordingly. Carbon atoms of residues lining the channel are colored green, while nitrogen, oxygen, and sulfur atoms are colored blue, red, and yellow, respectively.