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. Author manuscript; available in PMC: 2012 Oct 1.
Published in final edited form as: Prog Neurobiol. 2011 Aug 30;95(2):213–228. doi: 10.1016/j.pneurobio.2011.08.005

Figure 3.

Figure 3

Migration of Endogenous and Exogenous Stem Cells in the Acute and Chronic Phases of Stroke. Quinescent bone marrow-derived stem cells are mobilized and home to the site of injury via the CXCR4/SDF-1 signaling pathway during the acute phase of injury (Panel A). During the chronic stage of injury, the quantity of BM-derived stem cells that are mobilized and home to the ischemic site is greatly decreased (Panel B). Like endogenous stem cells, transplanted stem cells utilize the CXCR4/SDF-1 pathway to migrate to the site of injury during the acute phase of ischemia (Panel C) and the chronic phase of ischemia (Panel D).