Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Factors that are responsible for causing Alzheimer's disease (AD). Genetic mutations in amyloid precursor protein, presenilin 1 and presenilin 2 cause early-onset familial AD. Genetic variants in sortilin related receptor 1, clusterin, complement component receptor 1, CD2AP, CD33, EPHA1, &MS4A4/MS4A6E genes contribute to late-onset AD, in addition to ApoE 4/4 genotype. Aging, lifestyle activities and oxidative DNA damage are major contributing factors for the development of AD.
