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. Author manuscript; available in PMC: 2012 Oct 22.
Published in final edited form as: Mol Cell Endocrinol. 2011 Jun 1;346(1-2):102–109. doi: 10.1016/j.mce.2011.05.041

Figure 3.

Figure 3

A TACR3 positive family with IGD demonstrating complex autosomal recessive inheritance. Typical of an autosomal recessive pedigree, the affected family members with IGD are siblings and the mother is a carrier of a single TACR3 mutation. However, in true autosomal recessive inheritance, affected family members are expected to carry a genetic variant on each allele, while only one mutated allele has been identified in the affected members of this family. The microphallus seen in one of the brothers with IGD, as well as the neuroendocrine reversibility, can be subtle clues to suspect a TACR3 or TAC3 mutation..